Synthesis and Biological Evaluation of Novel Benzoxaboroles as Potential Antimicrobial and Anticancer Agents

Authors :: Joseph L. Johnson
Michael J. Williams
Venkatram R. Mereddy
Michael A. Corsello
Subash C. Jonnalagadda
Mohammad A. Alam
J. Sravan Kumar
Grady L. Nelson
Shirisha Gurrapu
Source :: Journal of Heterocyclic Chemistry. 50:814-820
Publication Year :: 2013
Publisher :: Wiley, 2013.
Abstract: Several novel benzoxaborole derivatives were synthesized starting from 2-formylphenylboronic acid utilizing Baylis–Hillman reaction, Barbier allylation, Passerini reaction, and aldol reaction protocols as the key step. All the synthesized benzoxaboroles have been evaluated for their antibacterial, antifungal, and anticancer activities.

Subjects :: Antifungal
Aldol reaction
medicine.drug_class
Chemistry
organic chemicals
Organic Chemistry
medicine
Organic chemistry
Antimicrobial
Passerini reaction
Biological evaluation

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