Nagashima-type palmoplantar keratosis with melanoma: absence of epidermal Langerhans cells in hyperkeratotic skin

Nagashima-type palmoplantar keratosis (PPK) is characterised by transgressive PPK with an autosomal recessive trait [1]. We describe a case of melanoma in a patient with Nagashima-type PPK.A 63-year-old Japanese woman presented with erythematous hyperkeratotic lesions on her palms and soles that had persisted since infancy. The lesions extended to the dorsal surfaces of the hands and feet and the Achilles tendon area, showing a whitish appearance after bathing. There was no family member with similar [...]