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Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

Authors :
Silvia Zibellini
Miguel A. Piris
Emanuele Zucca
Riccardo Dalla Favera
Michael Mian
Ivo Kwee
Francesco Forconi
Roberto Marasca
Elena Sozzi
Paola M.V. Rancoita
Gianluca Gaidano
Govind Bhagat
Manuela Mollejo
Andrea Rinaldi
Silvia Franceschetti
Fabio Facchetti
Alessandra Tucci
Luca Baldini
Luca Arcaini
Francesco Bertoni
Source :
British Journal of Haematology. 151:435-439
Publication Year :
2010
Publisher :
Wiley, 2010.

Abstract

Splenic marginal zone lymphomas (MZL) express mutated (M)) or unmutated (U)) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.

Details

ISSN :
00071048
Volume :
151
Database :
OpenAIRE
Journal :
British Journal of Haematology
Accession number :
edsair.doi...........4dd35de39b5b2d1ff360634c8a8838ef