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Outcomes Up to Age 36 Months after Congenital Zika Virus Infection – U.S. States

Authors :
Varsha Neelam
Kate R. Woodworth
Daniel J. Chang
Nicole M. Roth
Megan R. Reynolds
Amanda Akosa
Christopher P. Carr
Kayla N. Anderson
Sarah B. Mulkey
Roberta L. DeBiasi
Cara Biddle
Ellen H. Lee
Amanda L. Elmore
Sarah J. Scotland
Similoluwa Sowunmi
Nicole D. Longcore
Muhammad Ahmed
Peter H. Langlois
Salma Khuwaja
Shea Elizabeth Browne
Leah Lind
Kyoo Shim
Michael Gosciminski
Rachel Blumenfeld
Shreya Khuntia
Umme-Aiman Halai
Autumn Locklear
Mary Chan
Teri' Willabus
Julius Tonzel
Natalie S. Marzec
Nianest Alers Barreto
Connie Sanchez
Jane Fornoff
Shelby Hale
Amy Nance
Sowmya N. Adibhatla
Emily Potts
Elizabeth Schiffman
Devin Raman
Morgan F. McDonald
Brandi Stricklin
Elizabeth Ludwig
Lindsay Denson
Dianna Contreras
Paul A. Romitti
Emily Ferrell
Meghan Marx
Kimberly Signs
Amie Cook
Suzann Beauregard
Lucia C. Orantes
Laura Cronquist
Lesley Roush
Shana Godfred-Cato
Suzanne M. Gilboa
Dana Meaney-Delman
Margaret A. Honein
Cynthia A. Moore
Van T. Tong
Publication Year :
2023
Publisher :
Research Square Platform LLC, 2023.

Abstract

Background: To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. Methods: From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥ 1 follow-up exam after 14 days of age or with ≥ 1 visit with development reported, respectively. Results: Among 2,248 infants, 9.9% were born preterm, and 10.0% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1,881 children ≥ 1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥ 1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay. Conclusion: Understanding the prevalence of developmental delays and healthcare needs these children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........4de52f1398ab99118d2d4931544a4bb3