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Hydrothermal Generation of 3-Dimensional WO3 Nanocubes, Nanobars and Nanobricks, Their Antimicrobial and Anticancer Properties
- Source :
- Journal of Nanoscience and Nanotechnology. 21:5337-5343
- Publication Year :
- 2021
- Publisher :
- American Scientific Publishers, 2021.
-
Abstract
- In our current endeavor, 3-dimensional (3D) tungsten oxide (WO3) nanostructures (nanocubes, nanobars and nanobricks) have been swiftly generated via hydrothermal route at 160 °C for 24 h. Physico-chemical characterization of the resultant powder revealed formation of WO3 nanostructures with predominantly faceted cube, brick and rectangular bar-like morphology. The present study was also aimed at exploring the antimicrobial and anticancer potential of WO3 nanostructures. Antimicrobial activity was tested against different micro-organisms viz., Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Aspergillus fumigatus. The antibacterial and antifungal activity was ascertained against these micro-organisms by measuring the diameter of inhibition zone in agar well diffusion test which revealed that the resultant WO3 nanostructures acted as excellent antibacterial agents against both bacteria and fungi but were more effective against the fungus, A. fumigatus. To examine the growth curves of bacterial cells, time kill assay was monitored for E. coli, against which significant antibacterial action of WO3 nanostructures was noted. The anti-cancer activity of WO3 nanostructures was found to be concentration-dependent against KB cell line by viable cell count method. In our pilot study, WO3 nanostructures suspension with concentration in the range of 10−1 to 10−5 mg/ml was found to kill KB cells effectively.
- Subjects :
- Inhibition zone
Materials science
biology
Biomedical Engineering
Tungsten oxide
Bioengineering
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
medicine.disease_cause
biology.organism_classification
Antimicrobial
01 natural sciences
Hydrothermal circulation
0104 chemical sciences
Aspergillus fumigatus
Staphylococcus aureus
medicine
General Materials Science
0210 nano-technology
Escherichia coli
Bacteria
Nuclear chemistry
Subjects
Details
- ISSN :
- 15334880
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Nanoscience and Nanotechnology
- Accession number :
- edsair.doi...........4e471a37729d797fd5a4f43f5dddec15