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Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving
- Source :
- Journal of Pain Research. 13:909-918
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Objective Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in the brain of postherpetic neuralgia (PHN) patients are changeable. Methods Fifteen successfully treated PHN patients were enrolled ; the brain activity and structural abnormalities were detected and compared before and 6 months after treatment. The functional parameters were evaluated with resting-state functional MRI technique, i.e., the regional homogeneity (ReHo) and fractional amp litude of low-frequency fluctuation (fALFF). Structural changes were detected with voxel-based morphometry (VBM) and diffusion kurtosis imaging (DKI). Results Six months after pain relieving, PHN brain showed different ReHo and fALFF values in the frontal lobe, caudate, supramarginal gyrus, anterior cingulate cortex (ACC), cuneus, middle temporal gyrus, and cerebellum. In addition, VBM intensity in the cerebellum increased; DKI values decreased in the thalamus and increased in the temporal lobe after successful treatment. Conclusion Six months after pain relieving, functional and structural changes exist in PHN brain. Changes in some differential areas in PHN brain, such as ACC, frontal lobe, thalamus, and temporal lobe indicate that the central plasticity may be reversible after chronic pain relieving.
- Subjects :
- medicine.diagnostic_test
business.industry
Middle temporal gyrus
Chronic pain
medicine.disease
Temporal lobe
Cuneus
03 medical and health sciences
0302 clinical medicine
Anesthesiology and Pain Medicine
medicine.anatomical_structure
nervous system
Supramarginal gyrus
Frontal lobe
030202 anesthesiology
Anesthesia
medicine
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Anterior cingulate cortex
Subjects
Details
- ISSN :
- 11787090
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Pain Research
- Accession number :
- edsair.doi...........4e64c2012f29622e8da0eea15de46b65