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Gene of the month: APOL1
- Source :
- Journal of Clinical Pathology. 73:441-443
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- Apolipoprotein L1 (APOL1) is a protein encoded by the APOL1 gene, found only in humans and several primates. Two variants encoding two different isoforms exist for APOL1, namely G1 and G2. These variants confer increased protection against trypanosome infection, and subsequent African sleeping sickness, and also increase the likelihood of renal disease in individuals of African ancestry. APOL1 mutations are associated with increased risk of chronic kidney disease, inflammation, and exacerbation of systemic lupus erythematosus-associated renal dysfunction. This review serves to outline the structure and function of APOL1, as well as its role in several disease outcomes.
- Subjects :
- 0301 basic medicine
Gene isoform
Exacerbation
biology
business.industry
Apolipoprotein L1
030232 urology & nephrology
Inflammation
General Medicine
Disease
medicine.disease
Pathology and Forensic Medicine
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Increased risk
Immunology
biology.protein
Medicine
medicine.symptom
business
Gene
Kidney disease
Subjects
Details
- ISSN :
- 14724146 and 00219746
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Pathology
- Accession number :
- edsair.doi...........4e883b0a58f0522b0e090615a0ee2e08