Some metabolic and endocrine consequences in portacaval-shunted rats

Some metabolic and endocrine consequences of portacaval shunt were examined in rats eight weeks after the operation. Plasma levels of insulin, glucagon somatostatin, such as pancreatic content of insulin, glucagon, and somatostatin were determined by radioimmunoassay. Numerous biochemical parameters, such as the concentration of serum ammonia, transaminase (AST and ALT), urea bilirubin, total plasma protein and plasma albumin levels were determined by standard biochemical tests. Normal plasma levels of insulin and somatostatin hyperglucagonaemia were observed in rats with portacaval shunt. After portacaval shunt there was a highly significant increase (p