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RNA sequencing for the detection of MET exon 14 skipping in specimens with splice-site mutations

Authors :
Paris Petersen
Lauryn Keeler
Gregory Sims
Francesca Fike
Dana Weiner
Jeffrey Falk
Durga Prasad Cherukuri
Yu Xia
Armin Graber
Maya Panjikaran
Christopher J. Scott
Parth Sitlani
Richard Tseng
Source :
Journal of Clinical Oncology. 36:e24178-e24178
Publication Year :
2018
Publisher :
American Society of Clinical Oncology (ASCO), 2018.

Abstract

e24178Background: MET exon 14 skipping is detected in 2%-4% of NSCLC and is known to confer increased sensitivity to MET inhibitors. Over 100 distinct DNA sequence variants have been identified tha...

Details

ISSN :
15277755 and 0732183X
Volume :
36
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........50accf282256466445ea63ae52cff3f6
Full Text :
https://doi.org/10.1200/jco.2018.36.15_suppl.e24178