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Three new polyketides produced by Penicillium crustosum, a mycoparasitic fungus from Ophiocordyceps sinensis
- Source :
- Phytochemistry Letters. 36:150-155
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- A pair of novel benzannulated enantiomers, penilactone C [(+)-1 and (-)-1], a known related analogue 6-acetyl-2α,5-dihydroxy-2-(2-hydroxypropyl)-3α,8-dimethylchroman (3), and a novel polyketide, penilactone D (2), were obtained from the liquid-state and solid-state fermentation broth of Penicillium crustosum, a mycoparasitic fungus isolated from the fruiting body of Ophiocordyceps sinensis. The structures of these compounds were elucidated on the basis of spectroscopic data (HRESIMS, NMR and X-ray crystallography). The absolute configurations of enantiomers (+)-1 and (-)-1 were confirmed by TDDFT ECD calculation, and those of compound 2 were determined using Mo2-induced CD analysis. A plausible biogenetic pathway for 1 is proposed.
Details
- ISSN :
- 18743900
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi...........50c6e776f156b8b3242260249692a768