Su1755 Hydrogen Sulfide Exhibits a Potent Gastroprotective Action Against Stress-Induced Gastric Lesions. Involvement of Prostaglandins and Sensory Afferents

G A A b st ra ct s of the oxyntic mucosa, increased apoptosis, oxidative stress, and surface layer erosion. Inflammation was also observed in the mucosa as shown by the activation of the NFkB pathway and increases in TFF1, TIMP1 and Cox-2 expression. The pit region of the mucosa was affected by changes in cell interactions due to changes in beta-catenin and E-cadherin expression, loss of interaction in adherent junctions and activation of the beta-catenin pathway. Many of these changes, already detectable in 20-day-old fetuses, were specific of the offspring and were not observed in dams. All pups were refed a normal diet after weaning. We evaluated the persistence of stomach changes by comparing adult rats with MMD during gestation and suckling period and normal diet thereafter with control rats. The gastric mucosa thickness remained smaller in than that of control rats. SOD expression, NFkB activity, and apoptotic cell loss remained increased. CONCLUSIONS: These results indicate that the deleterious effects of MDD during gestation and lactation were accompanied by inflammatory and ulcerative states that were not reversed by the ingestion of a normal diet after weaning.