Predictive biomarkers of trabectedin (TR) and olaparib (OL) synergism in preclinical models of bone and soft tissue sarcoma (BSTS)

Authors :: Marco Basiricò
Lorenzo D'Ambrosio
Giovanni Grignani
Federica Capozzi
Raimondo Piana
Massimo Aglietta
Loretta Gammaitoni
Danilo Galizia
Maria Serena Benassi
Ymera Pignochino
Carmine Dell' Aglio
Annalisa Lorenzato
Dario Sangiolo
Source :: Journal of Clinical Oncology. 32:10569-10569
Publication Year :: 2014
Publisher :: American Society of Clinical Oncology (ASCO), 2014.
Abstract: 10569 Background: TR is a DNA damaging agent as 2nd line-therapy in STS. We speculated that its antitumor activity could be potentiated by a “synthetic lethality” approach targeting key molecules i...

Subjects :: Antitumor activity
Cancer Research
business.industry
Soft tissue sarcoma
Synthetic lethality
medicine.disease
Molecular biology
Olaparib
chemistry.chemical_compound
Oncology
chemistry
Cancer research
Medicine
business
Trabectedin
medicine.drug
Predictive biomarker

Tools