Back to Search
Start Over
Reduced interleukin-10 secretion at birth is associated with sensitization to furred pets during early childhood*1
- Source :
- Journal of Allergy and Clinical Immunology. 113:S244-S245
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Rationale Interleukin-10 (IL-10) response profiles and the timing and nature of environmental exposures may contribute to the development of allergic sensitization during early childhood. Methods Cord blood obtained from infants enrolled in the COAST project were stimulated in vitro with phytohemagglutinin (PHA) for 24 hours, and supernatant fluids were analyzed for IL-10 by ELISA. Values for IL-10 secretion were compared to allergen-specific IgE results evaluated at age 2 years for the following antigens: D. farinae, D. pteronyssinus, Alternaria alternata , dog dander, cat dander, milk, egg, peanut, and soy. Results Infants who were sensitized to any aeroallergen had significantly lower levels of IL-10 than those that were not (median 89.7 vs 107.4 pg/ml, p=0.04). When individual allergens were evaluated, IL-10 secretion profiles were not associated with sensitization to mites or Alternaria , but were significantly lower with both dog (median 73.7 vs 107.0 pg/ml, p=0.001) and cat (median 71.4 vs 107.3 pg/ml, p=0.007) sensitization. IL-10 secretion profiles were not associated with the development of food allergen sensitization (median 97.9 vs 104.6 pg/ml, p=0.18). Conclusions Reduced IL-10 responses at birth are associated with increased risk for the development of sensitization to some, but not all, allergens following early life exposures.
- Subjects :
- biology
business.industry
Immunology
Aeroallergen
Alternaria
biology.organism_classification
Immunoglobulin E
medicine.disease_cause
Alternaria alternata
Allergic sensitization
Interleukin 10
medicine.anatomical_structure
Cord blood
biology.protein
Immunology and Allergy
Medicine
business
Sensitization
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi...........532ff1774273bbbc821b64c575b17174