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RETRACTED ARTICLE: Early use of high-dose vitamin C is beneficial in treatment of sepsis
- Source :
- Irish Journal of Medical Science (1971 -). 190:1183-1188
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Vitamin C has shown benefits in patients with sepsis in addition to standard therapy recently. However, further evidence is required to verify the efficacy of vitamin C in clinical practice. This study aimed to investigate the effect of adjunctive intravenous high-dose vitamin C treatment on hospital mortality in patients with sepsis. One hundred seventeen patients with sepsis in our department from June 2017 to May 2019 were randomly divided into two groups: the control group (56 cases) and the vitamin C group (61 cases). The control group was treated by the routine and basic therapy with intravenous drip of 5% dextrose and placebo (100 ml/time, 2 times/day), while the vitamin C group was administered intravenously by 3.0 g vitamin C dissolved into 5% dextrose (100 ml/time, 2 times/day) based on the control group. The mortality and efficacy were statistically analyzed and compared between the two groups. The 28-day mortality differed significantly between the control group and the vitamin C group (42.97% vs. 27.93%) (p
- Subjects :
- medicine.medical_specialty
Vitamin C
business.industry
General Medicine
030204 cardiovascular system & hematology
medicine.disease
Placebo
Gastroenterology
Procalcitonin
Icu admission
Sepsis
03 medical and health sciences
0302 clinical medicine
Vasoactive
Internal medicine
Medicine
SOFA score
In patient
030212 general & internal medicine
business
Subjects
Details
- ISSN :
- 18634362 and 00211265
- Volume :
- 190
- Database :
- OpenAIRE
- Journal :
- Irish Journal of Medical Science (1971 -)
- Accession number :
- edsair.doi...........5399d8705b451eb904b9afe6784b28c3