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Arterial Lactate Concentration At The End of Liver Transplantation is Independently Associated with One-Year Mortality

Authors :
Didier Samuel
Eric Vibert
Jacques Duranteau
Joseph Rinehart
Brigitte Ickx
Jean Louis Vincent
Dessy Germanova
Philippe Van der Linden
Maya Moussa
Valerio Lucidi
Olivier Desebbe
Leonard Drouard
Salima Naili
Sean Coeckelenbergh
Alexandre Joosten
Publication Year :
2021
Publisher :
Research Square Platform LLC, 2021.

Abstract

BACKGROUNDLiver transplant patients who develop hyperlactatemia are at increased risk of postoperative morbidity and mortality, but there are few data on longer-term outcomes. We therefore investigated whether arterial lactate concentration obtained immediately after surgery, at the time of admission to the intensive care unit (ICU), was associated with 1-year mortality. METHODS: In this retrospective cohort study, all patients who underwent liver transplant surgery between September 2013 and December 2019 were screened for inclusion. Patients who underwent combined transplantation surgery and those with a history of previous liver transplantation (i.e., redo surgery) were not included. Logistic regression modeling included univariate and multivariate analyses. Receiver operating characteristic (ROC) curves and areas under the curves (AUROCs) were calculated. Lactate thresholds and association with outcome were analyzed for specificity, sensitivity, and Youden’s index.RESULTS: Of 226 patients included, 18.4% died within 1-year of liver transplantation. Immediate postoperative lactate concentration was independently associated with 1-year mortality with an odds ratio (OR) of 1.35 (95% CI: 1.16 to 1.59; pCONCLUSION: Increased arterial lactate concentration on admission to the ICU immediately after orthotopic liver transplantation is independently associated with increased 1-year mortality.Trial Registration: Not Applicable

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........53cf66cdc66c0edbdd338c741358148e
Full Text :
https://doi.org/10.21203/rs.3.rs-601997/v1