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Synthesis and biological activities of truncated acridone: Structure-activity relationship studies of cytotoxic 5-hydroxy-4-quinolone
- Source :
- Bioorganic & Medicinal Chemistry Letters. 7:789-792
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- A series of 5-hydroxy-4-quinolone ( 3 ) and 5-methoxy-4-quinolone ( 4 ) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor and antiherpes activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC 50 = 17.7 μM for HL60) which was greater than that of acronycine.
- Subjects :
- Bicyclic molecule
HL60
medicine.drug_class
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Quinolone
Biochemistry
Chemical synthesis
Combinatorial chemistry
In vitro
Acridone
chemistry.chemical_compound
chemistry
Drug Discovery
medicine
Molecular Medicine
Structure–activity relationship
Phenols
Molecular Biology
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........53f112b751729d0299e3625778d04798