Back to Search
Start Over
Silver nanoparticles for solvent-free detection of small molecules and mass-to-charge calibration of laser desorption/ionization mass spectrometry
- Source :
- Journal of Vacuum Science & Technology B. 37:012906
- Publication Year :
- 2019
- Publisher :
- American Vacuum Society, 2019.
-
Abstract
- This work aims at the utilization of nanostructured surfaces for advanced mass spectrometry [laser desorption/ionization mass spectrometry (LDI MS)]. The authors demonstrate that prepared nanostructures enable independent mass-to-charge calibration and also effectively substitute protonation agent for low-mass molecules instead of conventionally used matrices. Silver nanostructured surfaces were formed as homogeneous thin film, isolated nanoislands, and spherical nanoparticles. Besides the surface characterization, the paper focuses on the impact of LDI MS laser, irradiating the nanostructured surfaces, which results in the production of charged Ag clusters. Irradiated nanoparticle-based surfaces mostly provide single ionized species Ag+ while positive (Agn+, n ≤ 5) and negative ions (Agn−, n ≤ 7) were observed from the nanoislands film. It is shown that the ratio between particular ion line intensities can be tailored by the deposition time. The pattern of silver ions Agn (due to two natural isotopes) can be used for mass-to-charge calibration up to 1000 m/z. Additionally, the silver protonation improves the identification of small molecules. It is demonstrated on detection of sucrose (342.3 g/mol), fructose (180.2 g/mol), and creatinine (113.1 g/mol) molecules.
- Subjects :
- 010302 applied physics
Materials science
Process Chemistry and Technology
Analytical chemistry
Nanoparticle
Protonation
02 engineering and technology
021001 nanoscience & nanotechnology
Mass spectrometry
01 natural sciences
Silver nanoparticle
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ion
Ionization
0103 physical sciences
Materials Chemistry
Mass spectrum
Electrical and Electronic Engineering
Thin film
0210 nano-technology
Instrumentation
Subjects
Details
- ISSN :
- 21662754 and 21662746
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Vacuum Science & Technology B
- Accession number :
- edsair.doi...........54214f44663ba3451a0e21fbfffb25b6
- Full Text :
- https://doi.org/10.1116/1.5050878