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Five-year Changes in Body Composition in Type 2 Diabetes Mellitus Patients with a BMI < 32.5 kg/m2 Undergoing Laparoscopic Roux-en-Y Gastric Bypass Surgery

Authors :
Weizheng Li
Beibei Cui
Liyong Zhu
Xianhao Yi
Xulong Sun
Pengzhou Li
Guohui Wang
Jiapu Ling
Zhaomei Yu
Haibo Tang
Shaihong Zhu
Source :
Obesity Surgery.
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Information is scarce on the five-year effect of laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on body composition for Type 2 diabetes mellitus (T2DM) patients with a low BMI. This study aimed to evaluate the five-year changes in body composition in a Chinese T2DM cohort with a BMI &lt; 32.5 kg/m2 after LRYGB. Twenty-seven T2DM patients were assessed preoperatively (baseline) and 3 months, 6 months, 1 year, 3 years, and 5 years after LRYGB with dual-energy X-ray absorptiometry (DXA). DXA assessments were completed in 100%, 85%, 85%, 85%, 48%, and 37% at baseline and 3 months, 6 months, 1 year, 3 years, and 5 years, respectively. For the whole body, fat-free mass and muscle mass decreased from 6 months to 5 years after LRYGB (P &lt; 0.05), while bone mineral content decreased at 5 years after LRYGB (P &lt; 0.05). Fat mass of different regions decreased from 3 months to 1 year (P &lt; 0.05), and a similar magnitude of variation was observed in body fat mass percentage. A fat redistribution characterized by the regional fat proportion of trunk and android decreasing and the regional fat proportion of limbs gaining (P &lt; 0.05) occurred at 5 years after LRYGB. For low BMI patients with T2DM, LRYGB led to a short-term reduction in FM and a lasting reduction in FFM. A metabolically healthy fat redistribution occurring 5 years after LRYGB might be a promising mechanism to explain the lasting benefits of LRYGB for T2DM patients with a low BMI.

Details

ISSN :
17080428 and 09608923
Database :
OpenAIRE
Journal :
Obesity Surgery
Accession number :
edsair.doi...........54676489ee5a010439364fd28211484e