ChemInform Abstract: Synthesis, Crystal Structure Determination, and Biological Properties of the DNA-Dependent Protein Kinase (DNA-PK) Inhibitor 3-Cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035)

Authors :: Gabriele Fontana
Martin Stockley
Niall M. B. Martin
Roger John Griffin
Bernard T. Golding
Laurent Rigoreau
Graeme Cameron Murray Smith
William Clegg
Source :: ChemInform. 33
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035) is described. The structure of OK-1035 was validated by X-ray crystallography. An IC(50) value of 100 microM was determined for inhibition of DNA-PK, and this is approximately 12-fold higher than that reported previously.

Subjects :: chemistry.chemical_compound
chemistry
Stereochemistry
Biological property
DNA-Dependent Protein Kinase
Value (computer science)
General Medicine
Crystal structure
DNA

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