ChemInform Abstract: Simple and Efficient Preparation of 3-Substituted 6-(4-Chlorophenyl)-9-methyl-12H-[1]benzofuro[3,2-e][1,2,4]triazolo [4,3,b][1,2]diazepines via a Silylation-Amination Reaction

A series of new 3-substituted 6-(4-chlorophenyl)-9-methyl-12H-[1]benzofuro[3,2-e][1,2,4]triazolo[4,3-b][1,2]diazepines was synthesized from the corresponding bicyclic 1-(4-chlorophenyl)-3,5-dihydro-8-methyl-4H-[1]benzofuro[2,3-d][1,2]diazepin-4-one. The synthesis strategy makes use of silylation–amination as the key step, allowing a wide range of derivatives to be prepared. .