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Bioglass® 45S5-based composites for bone tissue engineering and functional applications
- Source :
- Journal of Biomedical Materials Research Part A. 105:3197-3223
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Bioglass® 45S5 (BG) has an outstanding ability to bond with bones and soft tissues, but its application as a load-bearing scaffold material is restricted due to its inherent brittleness. BG-based composites combine the amazing biological and bioactive characteristics of BG with structural and functional features of other materials. This article reviews the composites of Bioglass® in combination with metals, ceramics and polymers for a wide range of potential applications from bone scaffolds to nerve regeneration. Bioglass® also possesses angiogenic and antibacterial properties in addition to its very high bioactivity; hence, composite materials developed for these applications are also discussed. BG-based composites with polymer matrices have been developed for a wide variety of soft tissue engineering. This review focuses on the research that suggests the suitability of BG-based composites as a scaffold material for hard and soft tissues engineering. Composite production techniques have a direct influence on the bioactivity and mechanical behavior of scaffolds. A detailed discussion of the bioactivity, in vitro and in vivo biocompatibility and biodegradation is presented as a function of materials and its processing techniques. Finally, an outlook for future research is also proposed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3197-3223, 2017.
- Subjects :
- Materials science
Regeneration (biology)
Composite number
Metals and Alloys
Biomedical Engineering
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Bone tissue engineering
0104 chemical sciences
Biomaterials
In vivo biocompatibility
Brittleness
Bioglass 45S5
Scaffold material
visual_art
Ceramics and Composites
visual_art.visual_art_medium
Ceramic
Composite material
0210 nano-technology
Biomedical engineering
Subjects
Details
- ISSN :
- 15493296
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Materials Research Part A
- Accession number :
- edsair.doi...........551962fe3045de2b3063926373df500a
- Full Text :
- https://doi.org/10.1002/jbm.a.36156