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Bioglass® 45S5-based composites for bone tissue engineering and functional applications

Authors :
Wan Jefrey Basirun
Muhammad Rizwan
Mohd Hamdi
Source :
Journal of Biomedical Materials Research Part A. 105:3197-3223
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Bioglass® 45S5 (BG) has an outstanding ability to bond with bones and soft tissues, but its application as a load-bearing scaffold material is restricted due to its inherent brittleness. BG-based composites combine the amazing biological and bioactive characteristics of BG with structural and functional features of other materials. This article reviews the composites of Bioglass® in combination with metals, ceramics and polymers for a wide range of potential applications from bone scaffolds to nerve regeneration. Bioglass® also possesses angiogenic and antibacterial properties in addition to its very high bioactivity; hence, composite materials developed for these applications are also discussed. BG-based composites with polymer matrices have been developed for a wide variety of soft tissue engineering. This review focuses on the research that suggests the suitability of BG-based composites as a scaffold material for hard and soft tissues engineering. Composite production techniques have a direct influence on the bioactivity and mechanical behavior of scaffolds. A detailed discussion of the bioactivity, in vitro and in vivo biocompatibility and biodegradation is presented as a function of materials and its processing techniques. Finally, an outlook for future research is also proposed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3197-3223, 2017.

Details

ISSN :
15493296
Volume :
105
Database :
OpenAIRE
Journal :
Journal of Biomedical Materials Research Part A
Accession number :
edsair.doi...........551962fe3045de2b3063926373df500a
Full Text :
https://doi.org/10.1002/jbm.a.36156