Decompensated islet beta cell function in patients with chronic hepatitis B: a retrospective case-control study

Background Dysglycometabolism is often accompanied with decreased islet β cell function based on the homeostasis model assessment of β cell function (HOMA-β). In this study, we aimed to identify the difference in HOMA-β values between Chronic hepatitis B (CHB) and non-hepatitis B virus (non-HBV) patients.Methods The study included 110 CHB and 110 non-HBV patients matched according to gender, age, and body mass index. HOMA-β values were evaluated.Results Under the normal glucose tolerance(NGT) condition, the HOMA-β value of the CHB group was in the decompensated stage, and HOMA-β value of CHB was always lower than non-HBV patients (NGT, impaired glucose regulation, and diabetes mellitus: 47.53vs.124.19, 41.59vs.80.17, and 36.46vs.62.92mIU/mmol; t =−4.709, −2.042, and −2.091; P=0.000, 0.047, and 0.046, respectively).Conclusion Clinicians should focus on dysglycometabolism of patients with CHB.