ChemInform Abstract: Transition-Metal-Free Direct Alkylation of Aryl Tetrazoles via Intermolecular Oxidative C-N Formation

A transition-metal-free synthetic approach for constructing alkylated aryl tetrazoles has been developed using n-Bu4NI as the catalyst and t-BuOOH as the oxidant. It involves the direct C–N bond formation through sp3 C–H activation. A wide range of benzylic C–H substrates (or alkyl ethers) and aryl tetrazoles undergo this reaction smoothly to deliver the corresponding products in good yields.