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Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation
Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation
- Source :
- Blood. 75:2459-2464
- Publication Year :
- 1990
- Publisher :
- American Society of Hematology, 1990.
-
Abstract
- Chronic graft-versus-host disease (GVHD) is an important complication of bone marrow transplantation. We analyzed risk factors for chronic GVHD in 2,534 recipients of HLA-identical sibling transplants surviving at least 90 days after transplantation. The actuarial probability of developing chronic GVHD within three years posttransplant was 46% +/- 3% (95% confidence interval). The most important risk factor for chronic GVHD was acute GVHD. The 3-year probabilities of chronic GVHD were 28% +/- 3%, 49% +/- 5%, 59% +/- 6%, 80% +/- 9%, and 85% +/- 15% for persons with grades 0, I, II, III, and IV acute GVHD, respectively (P less than .0001). Among patients with no or grade I acute GVHD, recipient age greater than 20 years, use of non-T-cell depleted bone marrow, and alloimmune female donors for male recipients predicted a higher risk of chronic GVHD. When all three adverse risk factors were present, the probability of chronic GVHD was 62% among persons with no prior acute GVHD and 85% among those with grade I acute GVHD. Among patients with grade II through IV acute GVHD, no other risk factor predicted chronic GVHD. These data identify individuals who might benefit from treatment strategies aimed at changing the incidence of chronic GVHD.
- Subjects :
- medicine.medical_specialty
business.industry
Incidence (epidemiology)
Immunology
chemical and pharmacologic phenomena
Cell Biology
Hematology
medicine.disease
Biochemistry
Gastroenterology
Histocompatibility
Transplantation
surgical procedures, operative
medicine.anatomical_structure
Graft-versus-host disease
immune system diseases
Internal medicine
Immunopathology
medicine
Bone marrow
Risk factor
Complication
business
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi...........567de66d36db7179ad658b900009e2aa
- Full Text :
- https://doi.org/10.1182/blood.v75.12.2459.2459