Back to Search
Start Over
Reduced fine motor competence in children with ADHD is associated with atypical microstructural organization within the superior longitudinal fasciculus
- Source :
- Brain Imaging and Behavior. 15:727-737
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Recent work in healthy adults suggests that white matter organization within the superior longitudinal fasciculus (SLF) may, at least partly, explain individual differences in fine motor skills. The SLF is also often implicated in the neurobiology underlying attention deficit hyperactivity disorder (ADHD) as part of the attention network connecting frontal and parietal regions. While ADHD is primarily characterized by inattention, impulsivity and/or hyperactivity, atypical fine motor control is a common comorbid feature. This study aimed to investigate the association between reduced fine motor skills in ADHD and microstructural properties within the SLF. Participants were 55 right-handed children with ADHD and 61 controls aged 9–11 years. Fine motor control was assessed using the Grooved Pegboard task. Children underwent high angular resolution diffusion MRI. Following pre-processing, constrained spherical deconvolution tractography was performed to delineate the three SLF branches bilaterally. Children with ADHD showed significantly poorer fine motor performance relative to controls in the non-dominant hand, indicated by significantly slower left handed Grooved Pegboard task performance. This slower response time for the non-dominant (left) hand was significantly associated with reduced apparent fibre density within the right SLF I, and reduced right SLF I, II and III volume. This finding was independent of spatial attention performance. These data support previous reports indicating that children with ADHD have poorer fine motor performance than controls in their non-dominant hand, and indicates that the neurobiological basis for impaired fine motor control may involve white matter properties within the contralateral SLF. This suggests that white matter properties in fronto-parietal areas may have broader implications than attention.
- Subjects :
- medicine.medical_specialty
Cognitive Neuroscience
Audiology
Impulsivity
behavioral disciplines and activities
050105 experimental psychology
White matter
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
medicine
Attention deficit hyperactivity disorder
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
05 social sciences
Superior longitudinal fasciculus
Neuropsychology
Motor control
medicine.disease
Fine motor skill
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
Neurology (clinical)
medicine.symptom
Psychology
030217 neurology & neurosurgery
Tractography
Subjects
Details
- ISSN :
- 19317565 and 19317557
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Brain Imaging and Behavior
- Accession number :
- edsair.doi...........56e0e9b3fcd99456ae3b7a5e2b86f82c