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Abstract 16015: Exosome-mediated Reversal of Duchenne Cardiomyopathy
- Source :
- Circulation. 132
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Duchenne muscular dystrophy, a crippling genetic disease leading to premature death, affects the heart as well as skeletal muscle. Indeed, cardiomyopathy is the leading cause of death in Duchenne patients. There are no approved treatments for the cardiomyopathy, and novel Duchenne-specific experimental approaches such as exon skipping do not benefit the heart. Here we demonstrate that cardiosphere-derived cells (CDCs), which are in advanced clinical testing for therapeutic regeneration after myocardial infarction, reverse the key pathophysiological hallmarks of Duchenne cardiomyopathy (oxidative stress, inflammation, fibrosis and mitochondrial dysfunction) in mdx mice. Exosomes secreted by human CDCs reproduce the benefits of CDCs in mdx mice, and reverse mitochondrial dysfunction in human Duchenne cardiomyocytes. Both CDCs and their exosomes improve heart function in mdx mice (P
- Subjects :
- medicine.medical_specialty
business.industry
Duchenne muscular dystrophy
Cardiomyopathy
Skeletal muscle
Disease
medicine.disease
Exosome
Premature death
medicine.anatomical_structure
Physiology (medical)
Internal medicine
medicine
Cardiology
Cardiology and Cardiovascular Medicine
business
Cause of death
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi...........578804044ecb39bda913888cad6b59e3
- Full Text :
- https://doi.org/10.1161/circ.132.suppl_3.16015