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Abstract 16015: Exosome-mediated Reversal of Duchenne Cardiomyopathy

Authors :
Ronald G. Victor
Joshua I. Goldhaber
Baiming Sun
Allen M. Andres
Ahmed Ibrahim
Rachel E. Tobin
Martin K. Childers
Mark A. Aminzadeh
Eduardo Marbán
Angelo G. Torrente
Roberta A. Gottlieb
David Taylor
Prasanthi Durvasula
Xuan Guan
Source :
Circulation. 132
Publication Year :
2015
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2015.

Abstract

Duchenne muscular dystrophy, a crippling genetic disease leading to premature death, affects the heart as well as skeletal muscle. Indeed, cardiomyopathy is the leading cause of death in Duchenne patients. There are no approved treatments for the cardiomyopathy, and novel Duchenne-specific experimental approaches such as exon skipping do not benefit the heart. Here we demonstrate that cardiosphere-derived cells (CDCs), which are in advanced clinical testing for therapeutic regeneration after myocardial infarction, reverse the key pathophysiological hallmarks of Duchenne cardiomyopathy (oxidative stress, inflammation, fibrosis and mitochondrial dysfunction) in mdx mice. Exosomes secreted by human CDCs reproduce the benefits of CDCs in mdx mice, and reverse mitochondrial dysfunction in human Duchenne cardiomyocytes. Both CDCs and their exosomes improve heart function in mdx mice (P

Details

ISSN :
15244539 and 00097322
Volume :
132
Database :
OpenAIRE
Journal :
Circulation
Accession number :
edsair.doi...........578804044ecb39bda913888cad6b59e3
Full Text :
https://doi.org/10.1161/circ.132.suppl_3.16015