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Synthesis of N-1-Skatyl Uracil Derivatives
- Source :
- Chemistry of Natural Compounds. 53:333-337
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- N-1 skatyl derivatives were obtained in moderate yields via the reaction of uracil, 5-fluorouracyl, and cytosine with gramine N-oxide or its methyl iodide. Gramine N-oxide was converted into gramine in good yield upon microwave irradiation in DMF solution. Gramine was also formed in DMF solution in the presence of DBU from gramine methyl iodide although microwave irradiation did not affect the yield of gramine. Gramine did not form from its methyl iodide upon microwave irradiation without DBU.
- Subjects :
- 0301 basic medicine
Gramine
Uracil
Plant Science
General Chemistry
Medicinal chemistry
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
chemistry
Yield (chemistry)
Microwave irradiation
Cytosine
Methyl iodide
Subjects
Details
- ISSN :
- 15738388 and 00093130
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Chemistry of Natural Compounds
- Accession number :
- edsair.doi...........57ce47ae5edd5c105a894d122b597ce5