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Hyperhomocyst(e)inämie - ein unabhängiger Risikofaktor des Schlaganfalls

Authors :
Peter Schnider
Karl Zeiler
Wolfgang Lalouschek
Uhl F
Susanne Aull
Lueder Deecke
Source :
Fortschritte der Neurologie · Psychiatrie. 64:271-277
Publication Year :
1996
Publisher :
Georg Thieme Verlag KG, 1996.

Abstract

The total of free and protein-bound homocysteine including its derivatives is usually summarised as "homocyst(e)ine [H(e)]". Several congenital enzyme deficiencies may cause markedly elevated H(e) plasma levels, leading to the well-known clinical syndromes of homocystinuria. Recently, mild hyperhomocyst(e)inemia has been recognised as an independent risk factor for ischaemic cerebrovascular disease, coronary heart disease, and peripheral artery disease. H(e) levels are also related to the extent of atherosclerotic vessel wall alterations. The role of mild hyperhomocyst(e)inemia in venous thromboembolic disease, however, is not yet clear. A considerable proportion of patients with mild hyperhomocyst(e)inemia suffers from a deficiency of folate, vitamin B12, and/or vitamin B6. Supplementation of these agents--alone or combined with betain--leads to a decrease or even to a normalisation of elevated H(e) levels in the majority of such patients. Hitherto, no prospective randomised studies dealing with the clinical efficacy of such a--probably innocuous--supplementation have been performed. In the meantime, adequate alimentary intake of folate should be ensured.

Details

ISSN :
14393522 and 07204299
Volume :
64
Database :
OpenAIRE
Journal :
Fortschritte der Neurologie · Psychiatrie
Accession number :
edsair.doi...........5850845841e56b81f99450bcc2694865
Full Text :
https://doi.org/10.1055/s-2007-996395