A Special Focus on the Role of α1D-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

α1D-Adrenoceptors are involved in the genesis/maintenance of hypertension in spontaneously hypertensive rats (SHR). This study aims to investigate the role of α1D-adrenoceptors in the antinatriuretic and antidiuretic responses in SHR subjected to high sodium (SHRHNa) and normal sodium (SHRNNa) intake for six weeks. Renal inulin clearance study was performed in which the antinatriuretic and antidiuretic responses to phenylephrine were examined in the presence and absence of α1D-adrenoceptors blocker BMY7378. Data, mean±S.E.M. were subjected to ANOVA with significance at p