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EVALUATION OF SYNERGISTIC EFFECT OF Kaempferia galanga L. RHIZOME EXTRACTS ON THE ANTIBIOTIC ACTIVITY ANTIBIOTICS AGAINST BACTERIAL PATHOGENS
- Source :
- Journal of Tropical Pharmacy and Chemistry. 4:108-113
- Publication Year :
- 2018
- Publisher :
- Faculty of Pharmacy, Mulawarman University, 2018.
-
Abstract
- Background: aromatic ginger rhizome (Kaempferia galanga L.) is a member of Zingiberaceae family, has been known to have an antibacterial effect is used for everyday cooking spices, but the synergistic effect on broad spectrum antibiotics was unknown. Objective: this research was conducted to find out the synergistic effect of Kaempferia galanga L. Rhizome extract (KGR) on some broad-spectrum antibiotics against gram positive and negative bacterial pathogens in vitro. Method: KGR was taken from farmers in Samarinda City, East Kalimantan Province, Indonesia. Extraction by maceration with ethanol solvent. Antibacterial activity test of KGR ethanol extract, antibiotic and synergistic effect using Mueller-Hinton agar, Kirby-Bauer disc diffusion method on ampicillin, cefuroxime, chloramphenicol, ciprofloxacin, and meropenem antibiotics against Staphylococcus aureus and Escherichia coli. Results were expressed in percentage increase of the inhibition zone. Statistical test with t-test, significantly different if p
- Subjects :
- biology
Traditional medicine
medicine.drug_class
Chemistry
Chloramphenicol
Antibiotics
biochemical phenomena, metabolism, and nutrition
medicine.disease_cause
biology.organism_classification
Meropenem
Ciprofloxacin
Staphylococcus aureus
Ampicillin
medicine
Kaempferia galanga
Cefuroxime
medicine.drug
Subjects
Details
- ISSN :
- 24076090 and 20877099
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Tropical Pharmacy and Chemistry
- Accession number :
- edsair.doi...........589a02d9b2b5843314f868c65d9f4177