When phosphoryl azide meets mechanochemistry: clean, rapid, and efficient synthesis of phosphoryl amides under B(C6F5)3 catalysis in a ball mill

We described herein the first example associated with B(C6F5)3-catalyzed preparation of phosphoryl amides under mechanochemical conditions. In this novel system, the combination of energetic reagents with an energetic mechanochemical process enabled the reaction to proceed under very mild conditions and accelerated the desired nucleophilic attack on the phosphorus center.