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[4+n] Annulation Reactions Using ortho-Chloromethyl Anilines as Aza-ortho-Quinone Methide Precursors
- Source :
- Synthesis. 54:953-964
- Publication Year :
- 2021
- Publisher :
- Georg Thieme Verlag KG, 2021.
-
Abstract
- Aza-ortho-quinone methides are important reactive intermediates that have found broad applications in synthetic chemistry. Recently, 1,4-elimination of ortho-chloromethyl aniline derivatives has emerged as a novel, powerful and convenient method for aza-ortho-quinone methide generation. This review will highlight the recent applications of aza-ortho-quinone methide precursors in annulation reactions to access various biologically important nitrogen-containing heterocycles. The general mechanisms are briefly discussed as well.1 Introduction2 [4+n] Annulation Reactions Using ortho-Chloromethyl Anilines as Aza-ortho-Quinone Methide Precursors2.1 [4+2] Annulation Reactions2.2 [4+1] Annulation Reactions2.3 [4+3] Annulation Reactions3 Conclusion and Perspective
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........58fe70ccab354bfd4eab7e1c5e20b4fa