HER2 expression and extensive molecular characterization of resected brain metastases from colorectal cancer: The HEROES study

Authors :: Alessandra Prete
Francesca Bergamo
Rossana Intini
Sabina Murgioni
Maria Caterina De Grandis
Vittoria Matilde Piva
Giulia Barsotti
Francesca Daniel
Mario Domenico Rizzato
Roberta Salmaso
Valentina Angerilli
Giada Munari
Valentina Baro
Franco Chioffi
Valentina Vettore
Elena Carcea
Aldo Montagna
Vittorina Zagonel
Matteo Fassan
Sara Lonardi
Source :: Journal of Clinical Oncology. 40:2025-2025
Publication Year :: 2022
Publisher :: American Society of Clinical Oncology (ASCO), 2022.
Abstract: 2025 Background: Brain metastases (BM) from primary colorectal cancer (prCRC) are rare (1-3%); few is known about CRC BM predictive factors, prognosticators and molecular pathways. High rate of HER2 amplification ( HER2+) in CRC with BM was previously described, being HER2+ overall rare in CRC (

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