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Novel 4,5-bis(trifluoromethyl)-1H-pyrazoles through a concise sequential iodination-trifluoromethylation reaction

Novel 4,5-bis(trifluoromethyl)-1H-pyrazoles through a concise sequential iodination-trifluoromethylation reaction

Authors :
Andrizia F. Junges
Everton P. Pittaluga
Helio G. Bonacorso
Nilo Zanatta
Marcos A. P. Martins
Source :
Tetrahedron Letters. 60:1385-1388
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

An efficient protocol for the assembly of a new series of 1,3-disubstituted 4,5-bis(trifluoromethyl)-1H-pyrazoles – through a concise sequential iodination-trifluoromethylation reaction at the C-4 position of an initial series of 1-aryl-3-(alkyl/aryl)-5-trifluoromethyl-1H-pyrazoles (electronically deactivated heterocycles), using NIS and MFSDA, at good conversion yields and in short reaction times – is reported.

Details

ISSN :
00404039
Volume :
60
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........59bc24683660c542153e4a57c6a15899
Full Text :
https://doi.org/10.1016/j.tetlet.2019.04.031