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Novel 4,5-bis(trifluoromethyl)-1H-pyrazoles through a concise sequential iodination-trifluoromethylation reaction
Novel 4,5-bis(trifluoromethyl)-1H-pyrazoles through a concise sequential iodination-trifluoromethylation reaction
- Source :
- Tetrahedron Letters. 60:1385-1388
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- An efficient protocol for the assembly of a new series of 1,3-disubstituted 4,5-bis(trifluoromethyl)-1H-pyrazoles – through a concise sequential iodination-trifluoromethylation reaction at the C-4 position of an initial series of 1-aryl-3-(alkyl/aryl)-5-trifluoromethyl-1H-pyrazoles (electronically deactivated heterocycles), using NIS and MFSDA, at good conversion yields and in short reaction times – is reported.
Details
- ISSN :
- 00404039
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........59bc24683660c542153e4a57c6a15899
- Full Text :
- https://doi.org/10.1016/j.tetlet.2019.04.031