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IL‐10 promotes malignant pleural effusion by regulating T H 1 response via an miR‐7116‐5p/GPR55/ERK pathway in mice
- Source :
- European Journal of Immunology. 50:1798-1809
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural effusion (MPE) and significantly enhanced miR-7116-5p expression in pleural CD4+ T cells. We demonstrated that miR-7116-5p suppressed IL-10-mediated MPE formation by inhibiting pleural vascular permeability as well as tumor angiogenesis and tumor growth. IL-10 promoted MPE formation by suppressing miR-7116-5p that enhances TH 1 response. We identified G protein-coupled receptor 55 (GPR55) as a potential target of miR-7116-5p, and miR-7116-5p promoted TH 1 cell function by downregulating GPR55. Moreover, GPR55 promoted MPE formation by inhibiting TH 1 cell expansion through the ERK phosphorylation pathway. These results uncover an IL-10-mediated pathway controlling TH 1 cells and demonstrate a central role for miR-7116-5p/GPR55/ERK signaling in the physiological regulation of IL-10-driven pro-malignant responses.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
medicine.medical_treatment
Immunology
Vascular permeability
Biology
medicine.disease
03 medical and health sciences
Interleukin 10
030104 developmental biology
0302 clinical medicine
Cytokine
Immune system
GPR55
medicine
Cancer research
Immunology and Allergy
Malignant pleural effusion
Receptor
030215 immunology
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi...........59cf4496af43a4c104d9bef99eb1ecd3