Comparison of cisplatin induced nephrotoxicity with short hydration or conventional hydration in gastric cancer: A retrospective study

211 Background: Cisplatin is administered in combination with massive and long term hydration to avoid renal toxicity. Although a short hydration protocol for cisplatin has been recently developed in lung cancer, which in gastric cancer has not been well clarified. We modified our XPT (capecitabine / cisplatin / trastuzumab) regimen, adopting short hydration method. This study was conducted to compare the preventive effect for renal toxicity of XPT therapy between the short hydration regimen and the conventional regimen. Methods: Medical records of patients with gastric cancer who received XPT therapy containing cisplatin at a dose of ≥ 80 mg/m2 were reviewed for 3 cycles of the observational period. Patients received either the short hydration regimen or the conventional regimen; short hydration regimen consisted of 2200 - 2500 mL of hydration over a period of 6.2 hours with furosemide and magnesium supplementation on day 1 and 1050 mL of hydration over 4 hours on day2 and 3, and the conventional regimen consisted of 3200 - 3500 mL of hydration over 24 hours on day 1 and 1550 ml of hydration over 6 hours on day2 and 3. Renal toxicity was then compared between the two groups. Results: Out of the total 31 patients, 6 received the short hydration regimen and 25 received conventional regimen. An elevated serum creatinine level ≥ grade 1 was significantly less frequent in the group receiving the short hydration regimen (0%, 0/6) than in the group receiving the conventional regimen (48.0%, 12/25) ( P < 0.05). The completion rate for the planned treatment in the short hydration group (100.0%, 6/6) was higher than that in the conventional hydration group (84.0%, 21/25). Conclusions: Based on the results of this study, short hydration may be a feasible regimen for XPT therapy in gastric cancer.