Botulinum Toxin Bladder Injection in the Treatment of Neurogenic Detrusor Overactivity and Idiopathic OAB

Over the last 50 years, botulinum toxin (BoNT) has been transformed from a cause of life-threatening disease to an effective therapy, mainly for muscle spasticity, blepharospasm, and bladder overactivity. Certainly the use of intradetrusor BoNT for the treatment of DO has revolutionized the care of patients with neurogenic bladder and iOAB, largely improving their quality of life. A recent growing body of evidence suggests that intradetrusor injection of BoNT may have beneficial effects in patients with refractory detrusor overactivity (DO) for conservative and/or medical treatments, and it is a new minimally invasive alternative to bladder augmentation in patients with severe overactive bladder (OAB) symptoms and/or untreatable neurogenic bladder.