Therapeutic Efficacy of Enterosorbents on the Model of Chronic Endotoxicosis

A comparative evaluation of detoxification properties of a powder of brown peat moss’s turf, activated charcoal and polisorb has been studied on a model of chronic endotoxicosis, simulated by the administration of tetrachloromethane and lipopolysaccharide S. thyphi to the experimental animals. The effectiveness of the investigated objects has been evaluated by their effect on serum biochemical parameters and histology of liver and kidney. The administration of tetrachloromethane and lipopolysaccharide to the rats in the chronic experiment has shown statistically significant increase of aspartataminotransferase, alaninaminotransferase and malondialdehyde, and have been decreased significantly protein and urea in serum. The administration of powder of brown peat moss’s turf to the animals with experimental chronic endotoxicosis has limited the toxicity of tetrachloromethane and lipopolysaccharide. This has been resulted in lower activities of aspartataminotransferase and alaninaminotransferase, and level of malondialdehyde. But levels of protein and urea have been increased in serum, that indicating of a partial normalization functions of liver. Thus, the course administration of investigated sorbents in steady of experimental chronic endotoxicosis is accompanied by a significant decrease of endotoxic reaction associated with disruption of the structure and functions of the cells of liver. The detoxification activity of the powder of brown peat moss’s turf doesn’t yield to the effects of polisorb and activated charcoal.