Observation on the effect of Nd: YAG 1064nm laser combined with topical tranexamic acid on chloasma

Object To observe the clinical effect of Q-switch Nd: YAG 1064nm laser combined with tranexamic acid on chloasma. Methods 140 cases of chloasma patients were enrolled in our clinic laser center from January 2018 to October 2018 and randomly divided into basic treatment group and combination treatment group. 70 cases in each group. Patients in the basic treatment group were treated with Q-switch Nd: YAG 1064nm laser. All patients received 10 times treatments at a 10-days interval. The combination group was treated with laser combination topical tranexamic acid, 2-4 drops twice a day for 12 weeks. Every patient should be anti-sun burn during the treatment period. After treatment, the clinical efficacy of the two groups was analyzed. Results After treatment, MASI scores of patients in the basic treatment group were significantly lower than those in the combination treatment group, and the difference was statistically significant $(\mathrm{P}\lt 0.05)$. The effective rate of combination treatment group was 81.43%, which is higher than that of the basic treatment group (65.71%). Two groups of comparison, the curative effect of the combination treatment group was better than that of the basic treatment group ($X^{2}=4.568, \mathrm{P}\lt 0.05)$. The satisfaction of the basic treatment group was 85.71%, and that of the combination treatment group was 95.7%. The satisfaction of the basic treatment group was significantly higher than that of the combination treatment group. No severe adverse reactions were observed in all patients. Conclusions The efficacy of Q-switch Nd:YAG 1064nm laser combined with tranexamic acid for the treatment of chloasma was better than that of single laser therapy. It can significantly improve clinical outcome, increase the satisfaction of patients. It is worthy of clinical application.