Safety and Impact of Direct Left Atrial Pressure Monitoring in Patients Undergoing Continuous-Flow Left Ventricular Assist Device Implantation

Purpose Hemodynamic monitoring plays a critical role in the perioperative management of patients supported by continuous-flow left ventricular assist devices (CF-LVAD). Data published on left atrial pressure monitoring (LAPm) in patients with CF-LVAD support is limited. Our primary aim was to examine the safety and impact of direct LAPm in patients undergoing CF-LVAD implantation. Methods Retrospective data on demographics, LAPm, hemodynamics, and endpoints were extracted on patients at our institution with CF-LVAD implants from January 2017-June 2019. The decision to use a LAPm is based on institutional standards related to right ventricular failure risk and/or presence of severe pulmonary hypertension. The primary safety endpoint of LAPm was a composite of mediastinal bleeding requiring transfusion, cardiac tamponade, and LA thrombus. Secondary endpoints were LAPm device malfunction leading to premature LAPm removal and lack of hemodynamic trends, air embolism, surrogates of left ventricular (LV) unloading, inhaled epoprostenol use, and post-implant ICU and hospital length of stay (LOS). Statistical analyses were by two-tailed Student's t-test or chi-square tests (SAS, version 9.4). Results Of the 242 patients (mean age 58.1 ± 11.0 years), 88.4% had durable centrifugal pumps for destination therapy (58.3%). Most had Intermacs status 2-4 (95.5%) at implant. One hundred fifty-three patients (63.2%) had LAPm for a median of 20h. Prior to LAPm explant, 90.2% had an LAP Conclusion Use of LAPm to guide management is both safe and feasible in patients requiring CF-LVADs. In the vast majority of this cohort, we were able to achieve optimal LV unloading. Future analyses are warranted to better understand the clinical outcomes’ associations of LAPm on CF-LVAD parameters.