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7α-methoxy-2-[(substituted)methylene]cephem sulfones as inhibitors of human leukocyte elastase and thrombin
- Source :
- Chemistry of Heterocyclic Compounds. 34:1282-1288
- Publication Year :
- 1998
- Publisher :
- Springer Science and Business Media LLC, 1998.
-
Abstract
- A series of 7α-methoxy-2-[(substituted)methylene]cephem sulfones was synthesized. The compounds with an acetoxy group at the C-3′ position as a leaving group were found to be potent inhibitors of HLE. Selected compounds are also found to be antithrombin agents.
Details
- ISSN :
- 15738353 and 00093122
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Chemistry of Heterocyclic Compounds
- Accession number :
- edsair.doi...........5c621f29cf73b730efd66b989d53642e
- Full Text :
- https://doi.org/10.1007/bf02256808