Interobserver Agreement in the Diagnosis of Parkinson Disease with Cardiac 123I-Metaiodobenzylguanidine Scintigraphy

Rationale: The aim of this study was to analyse the interobserver agreement of visual and quantitative assessment of cardiac 123I-MIBG scintigraphy. Methods: Planar images were acquired using a low-energy collimator. The heart-to-mediastinal ratio (HM ratio) was adjusted for the use of a low-energy collimator, using a published formula. Interpretation was undertaken on both visual interpretation and following the addition of adjusted HM ratios. Images were classified as normal, abnormal or borderline. Results: The cohort consisted of 10 patients. On visual interpretation only, there was strong agreement on the interpretation of the scan, κ = .82, p