In vivo investigation of cobalt ferrite-based magnetic fluid and magnetoliposomes using morphological tests

Morphological studies were carried out after endovenous injection of a magnetic fluid and magnetoliposome samples, all containing cobalt ferrite magnetic nanoparticles (MNPs). Twenty four hours after injection, the three investigated samples presented differences concerning blood clearance, phagocytosis susceptibility, and MNP cluster size and amount. Our data suggest that the samples investigated are biocompatible and could be used as material basis for biomedical applications. Further, differences observed in the in vivo tests support application of the samples for different biomedical purposes.