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Polyethylene oxide–polyacrylic acid–folic acid (PEO‐PAAc) nanogel as a 99m Tc targeting receptor for cancer diagnostic imaging
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 64:534-547
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Nanoparticles are frequently used as targeting delivery systems for therapeutic and diagnostic radiopharmaceuticals. Polyethylene oxide-polyacrylic acid (PEO-PAAc) nanogel was prepared via γ-radiation-induced polymerization. Variable factors affecting nanoparticles size were investigated. The nanogel was radiolabeled with the imaging radioisotope 99m Tc and finally conjugated with folic acid to target folate receptor actively. PEO-PAAc-folic acid gel was characterized by dynamic light scattering (DLS) and atomic force microscopy (AFM). Biodistribution was studied in normal mice and solid tumor-bearing mice via intravenous and intratumor injections of the radiolabeled PEO-PAAc-folic acid nanogel. Results of biodistribution showed high selective uptake of the prepared complex in tumor muscle compared with normal muscle for both intravenous and intratumor injections. The T/NT ratio was found to be 6.186 and 294.5 for intravenous and intratumor injections, respectively. Consequently, 99m Tc-PEO-PAAc-folic acid complex could be a promising agent for cancer diagnostic imaging.
- Subjects :
- Biodistribution
Organic Chemistry
Polyacrylic acid
technology, industry, and agriculture
Conjugated system
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
chemistry
Dynamic light scattering
Polymerization
Folate receptor
Drug Discovery
Biophysics
Radiology, Nuclear Medicine and imaging
Technetium-99m
Spectroscopy
Nanogel
Subjects
Details
- ISSN :
- 10991344 and 03624803
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi...........5e9a0a1910001a7549840c07b1d826d4