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ChemInform Abstract: One-Pot Cascade Trifluoromethylation/Cyclization of Imides: Synthesis of α-Trifluoromethylated Amine Derivatives
- Source :
- ChemInform. 45
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Tryptamine- and phenethylamine-derived imides were selectively monotrifluoromethylated using CF3TMS. Subsequent methanesulfonic acid mediated cyclization of the intermediate hemiaminals afforded the α-trifluoromethylated amine derivatives via the formation of trifluoromethylated acyliminium ions, in one pot. The strategy was applicable to the both inter- and intramolecular versions. Furthermore, the utility of the present method was demonstrated through the synthesis of trifluoromethylated analogues of harmicine and crispine A.
Details
- ISSN :
- 09317597
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........5e9a53874f57f8f870c405e2b61fc34e