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Time-resolved contrast-enhanced three-dimensional pulmonary MR-angiography: 1.0 M gadobutrol vs. 0.5 M gadopentetate dimeglumine

Authors :
Fabian Kiessling
Stefan Delorme
Radko Krissak
Christian Fink
Astrid Schmähl
Ivan Zuna
Matthias P. Lichy
Michael Bock
Hans-Ulrich Kauczor
Source :
Journal of Magnetic Resonance Imaging. 19:202-208
Publication Year :
2004
Publisher :
Wiley, 2004.

Abstract

Purpose To compare contrast characteristics and image quality of 1.0 M gadobutrol with 0.5 M Gd-DTPA for time-resolved three-dimensional pulmonary magnetic resonance angiography (MRA). Materials and Methods Thirty-one patients and five healthy volunteers were examined with a contrast-enhanced time-resolved pulmonary MRA protocol (fast low-angle shot [FLASH] three-dimensional, TR/TE = 2.2/1.0 msec, flip angle: 25°, scan time per three-dimensional data set = 5.6 seconds). Patients were randomized to receive either 0.1 mmol/kg body weight (bw) or 0.2 mmol/kg bw gadobutrol, or 0.2 mmol/kg bw Gd-DTPA. Volunteers were examined three times, twice with 0.2 mmol/kg bw gadobutrol using two different flip angles and once with 0.2 mmol/kg bw Gd-DTPA. All contrast injections were performed at a rate of 5 mL/second. Image analysis included signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements in lung arteries and veins, as well as a subjective analysis of image quality. Results In patients, significantly higher SNR and CNR were observed with Gd-DTPA compared to both doses of gadobutrol (SNR: 35–42 vs.17–25; CNR 33–39 vs. 16–23; P ≤ 0.05). No relevant differences were observed between 0.1 mmol/kg bw and 0.2 mmol/kg bw gadobutrol. In volunteers, gadobutrol and Gd-DTPA achieved similar SNR and CNR. A significantly higher SNR and CNR was observed for gadobutrol-enhanced MRA with an increased flip angle of 40°. Image quality was rated equal for both contrast agents. Conclusion No relevant advantages of 1.0 M gadobutrol over 0.5 M Gd-DTPA were observed for time-resolved pulmonary MRA in this study. Potential explanations are T2/T2*-effects caused by the high intravascular concentration when using high injection rates. J. Magn. Reson. Imaging 2004;19:202–208. © 2004 Wiley-Liss, Inc.

Details

ISSN :
10531807
Volume :
19
Database :
OpenAIRE
Journal :
Journal of Magnetic Resonance Imaging
Accession number :
edsair.doi...........5f344e40e80cb6ad460734674390c321
Full Text :
https://doi.org/10.1002/jmri.10452