ChemInform Abstract: Highly Regio- and Stereo-Selective Alkyl Substitution with Copper Reagents for the Construction of Chiral Trifluoromethylated Quaternary Carbon Centres

Authors :: Takashi Yamazaki
Shuichi Hiraoka
Tomoya Kitazume
Source :: ChemInform. 28
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: A new route for the asymmetric construction of quaternary carbon centres containing a trifluoromethyl group has been established using a highly regio- and stereo-selective S N 2′ reaction of organocopper and organocuprate reagents with allylic mesylates 4 and 8.

Subjects :: chemistry.chemical_compound
Allylic rearrangement
Trifluoromethyl
chemistry
Group (periodic table)
Reagent
Alkyl substitution
chemistry.chemical_element
General Medicine
Medicinal chemistry
Copper
Quaternary carbon

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