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Meprin Phenotype and Cyclosporin A Toxicity in Mice
- Source :
- Advances in Experimental Medicine and Biology ISBN: 9781461283133
- Publication Year :
- 1988
- Publisher :
- Springer US, 1988.
-
Abstract
- Meprin is a membrane-bound metallo-proteinase that is present in high concentrations in the kidney brush border of mice and rats (Bond and Beynon, 1986). The enzyme has been purified and found to exist as a tetrameric glycoprotein that contains one mol zinc and three mol calcium per 85,000 molecular weight subunit (Beynon et al., 1981; Butler et al., 1987). Meprin hydrolyzes a variety of peptide and protein substrates (e.g., insulin B chain, glucagon, angiotensins I and II, bradykinin, hemoglobin, casein, aldolase, and phosphorylase kinase); the substrate used most often to assay activity is azocasein, a good general substrate for neutral and alkaline proteinases.
Details
- ISBN :
- 978-1-4612-8313-3
- ISBNs :
- 9781461283133
- Database :
- OpenAIRE
- Journal :
- Advances in Experimental Medicine and Biology ISBN: 9781461283133
- Accession number :
- edsair.doi...........5f69ef02af558bd65365ac9181030221