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Voltammetric studies of the interaction of 6-mercaptopurine with cucurbit[7]uril and DNA

Authors :
Si-Huang Zhong
Ying Huang
Yan-Hui Ma
Sai-Feng Xue
Qian-Jiang Zhu
Zhu Tao
Source :
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 69:131-137
Publication Year :
2010
Publisher :
Springer Science and Business Media LLC, 2010.

Abstract

The interaction of 6-mercaptopurine (6-MP), an antitumor drug, with cucurbit[7]uril (Q[7]) and DNA in an acetate buffer solution was studied by differential pulse voltammetry (DPV) and cyclic voltammetry(CV). The electrochemical data indicated a 1:1 complex formation of 6-MP with Q[7] and DNA. The formation constants of these complexes were determined based on the variations in the current. Moreover, the interactions of the 6-MP-Q[7] inclusion complex with DNA have been investigated by means of voltammetry. The results suggested that 6-MP displayed a high affinity for Q[7] and that the inclusion complex did not decompose when it bound to DNA. It can be inferred from the experimental data that the binding model of 6-MP to DNA may be ‘electrostatic binding’. In addition, the formation of inclusion complexes between Q[7] and 6-MP was confirmed by UV-Vis spectroscopy and the 1H NMR technique.

Details

ISSN :
15731111 and 09230750
Volume :
69
Database :
OpenAIRE
Journal :
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Accession number :
edsair.doi...........5fe49ac1f6c96dfdf0bcf656db37937e
Full Text :
https://doi.org/10.1007/s10847-010-9823-3