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Comparison of adhesion prevention capabilities of the modified starch powder-based medical devices 4DryField® PH and Arista™ AH in the Optimized Peritoneal Adhesion Model

Authors :
Lavinia Neubert
Juergen Klempnauer
Danny Jonigk
Daniel Poehnert
Markus Winny
Paul Borchert
Source :
International Journal of Medical Sciences. 16:1350-1355
Publication Year :
2019
Publisher :
Ivyspring International Publisher, 2019.

Abstract

Adhesion barriers can be based on numerous substances. In the rat Optimized Peritoneal Adhesion Model (OPAM) the starch-based hemostats 4DryField and Arista were tested for their capability to act in a preventive manner against adhesion formation (applied as a powder that was mixed in situ with saline solution to form a barrier gel). Adhesions were scored using the established scoring systems by Lauder and Hoffmann, as well as histopathologically using the score by Zuhlke. Animals receiving saline solution were used as controls. As previously published, 4DryField reduced peritoneal adhesions significantly. However, Arista did not lead to a statistically significant reduction of adhesion formation. When comparing 4DryField and Arista applied in the same manner, only 4DryField was significantly effective in preventing peritoneal adhesions. Histopathological evaluations confirmed the results of the macroscopic investigation, leading to the conclusion that starch-based hemostats do not generally have the capability to function as effective adhesion prevention devices.

Details

ISSN :
14491907
Volume :
16
Database :
OpenAIRE
Journal :
International Journal of Medical Sciences
Accession number :
edsair.doi...........604e0647dc0d6982d0badfd9089a2677
Full Text :
https://doi.org/10.7150/ijms.33277